Search Result

Results for "

catalytic activity

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Adenylate Cyclase (1) Aminoacyl-tRNA Synthetase (1) Antibiotic (2) Apoptosis (6) Aurora Kinase (1) Autophagy (2) Bacterial (5) Beta-secretase (1) Biochemical Assay Reagents (8) c-Met/HGFR (1) CaMK (2) Cholinesterase (ChE) (2) COX (2) Cytochrome P450 (1) DNA-PK (1) DNA/RNA Synthesis (2) DOCK (1) Endogenous Metabolite (1) ERK (3) FAAH (1) Fatty Acid Synthase (FASN) (1) FBPase (1) Fluorescent Dye (2) Fungal (3) Glucosidase (1) Glutathione S-transferase (1) Histone Methyltransferase (2) HIV (1) HIV Integrase (1) HSV (1) Influenza Virus (1) Interleukin Related (1) Keap1-Nrf2 (1) MEK (2) Orthopoxvirus (1) p38 MAPK (1) Parasite (2) PARP (1) Phosphatase (2) PKA (1) PKC (1) PROTACs (2) Proteasome (3) Ras (1) Reactive Oxygen Species (3) Ser/Thr Protease (1) Tie (1) Topoisomerase (3) Tyrosinase (1)
By Research Areas:	Cancer (27) Cardiovascular Disease (2) Endocrinology (1) Infection (10) Inflammation/Immunology (8) Metabolic Disease (11) Neurological Disease (11)

By Targets:

Adenylate Cyclase (1)

Aminoacyl-tRNA Synthetase (1)

Antibiotic (2)

Apoptosis (6)

Aurora Kinase (1)

Autophagy (2)

Bacterial (5)

Beta-secretase (1)

Biochemical Assay Reagents (8)

c-Met/HGFR (1)

CaMK (2)

Cholinesterase (ChE) (2)

COX (2)

Cytochrome P450 (1)

DNA-PK (1)

DNA/RNA Synthesis (2)

DOCK (1)

Endogenous Metabolite (1)

ERK (3)

FAAH (1)

Fatty Acid Synthase (FASN) (1)

FBPase (1)

Fluorescent Dye (2)

Fungal (3)

Glucosidase (1)

Glutathione S-transferase (1)

Histone Methyltransferase (2)

HIV (1)

HIV Integrase (1)

HSV (1)

Influenza Virus (1)

Interleukin Related (1)

Keap1-Nrf2 (1)

MEK (2)

Orthopoxvirus (1)

p38 MAPK (1)

Parasite (2)

PARP (1)

Phosphatase (2)

PKA (1)

PKC (1)

PROTACs (2)

Proteasome (3)

Ras (1)

Reactive Oxygen Species (3)

Ser/Thr Protease (1)

Tie (1)

Topoisomerase (3)

Tyrosinase (1)

By Research Areas:

Cancer (27)

Cardiovascular Disease (2)

Endocrinology (1)

Infection (10)

Inflammation/Immunology (8)

Metabolic Disease (11)

Neurological Disease (11)

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P2208

Z-IETD-AFC

Fluorescent Dye Cancer

Z-IETD-AFC, a specific fluorescence substrate, can be used to determine the caspase-8 catalytic activity .

Z-IETD-AFC	Fluorescent Dye	Cancer
Z-IETD-AFC, a specific fluorescence substrate, can be used to determine the caspase-8 catalytic activity .

HY-P3414A

Proteasome-activating peptide 1 TFA 1 Publications Verification	Proteasome	Neurological Disease
Proteasome-activating peptide 1 TFA is a peptide and a potent proteasome activator. Proteasome-activating peptide 1 TFA increases the chymotrypsin-like proteasomal catalytic activity and, consequently, proteolytic rates both in vitro and in culture. Proteasome-activating peptide 1 TFA prevents protein aggregation in a cellular model of amyotrophic lateral sclerosis .

HY-P3811A

Autocamtide-3 acetate	CaMK	Neurological Disease
Autocamtide-3 acetate, a 13-amino-acid peptide containing Thr287, is a selective CaMKII (Ca ²⁺/calmodulin-dependent kinase II) (CaMK) substrate .

HY-P3811

Autocamtide-3

CaMK Neurological Disease

Autocamtide-3, a 13-amino-acid peptide containing Thr287, is a selective CaMKII (Ca ²⁺/calmodulin-dependent kinase II) (CaMK) substrate .

Autocamtide-3	CaMK	Neurological Disease
Autocamtide-3, a 13-amino-acid peptide containing Thr287, is a selective CaMKII (Ca ²⁺/calmodulin-dependent kinase II) (CaMK) substrate .

HY-158038

AurkA allosteric-IN-1	Aurora Kinase	Cancer
AurkA allosteric-IN-1 (compound 6h) is an Aurora A (AurkA) inhibitor (IC₅₀: 6.50 μM) that inhibits the catalytic activity and non-catalytic functions of Aurora A. Aurora A regulates the assembly of the bipolar mitotic spindle and the fidelity of chromosome segregation during mitosis and has non-catalytic functions. AurkA allosteric-IN-1 blocks the interaction of AurkA with the activator TPX2 by binding to the Y pocket of AurkA .

HY-W054146

RAMB4 1 Publications Verification	Proteasome	Cancer
RAMB4 is a ubiquitin-proteasome system (UPS)-stressor. RAMB4 inhibits ubiquitin-mediated protein degradation upstream of the 20S proteasomal catalytic activites. RAMB4 triggers a ubiquitin-proteasome-system (UPS)-stress response without affecting 20S proteasome catalytic activities. Anticancer activity .

HY-13565

Becatecarin NSC 655649; BMS 181176; BMY 27557	Topoisomerase	Cancer
Becatecarin is a rebeccamycin analog with antitumor effects. Becatecarin intercalates into DNA and inhibites the catalytic activity of topoisomerases I/II.

HY-N2912

Axillaridine A	Cholinesterase (ChE)	Neurological Disease
Axillaridine A can be isolated from Sarcococca hookeriana var. digyna. Axillaridine A inhibits the catalytic activity of AChE .

HY-132941

CFT-2718

PROTACs Cancer

CFT-2718 is a new BRD4-targeting degrader (PROTAC) with enhanced catalytic activity and in vivo properties.
HY-P3918

EGF-R (661-681) T669 Peptide

p38 MAPK Others

EGF-R (661-681) T669 Peptide is a MAPK substrate that can used to measure MAPK catalytic activity .

CFT-2718	PROTACs	Cancer
CFT-2718 is a new BRD4-targeting degrader (PROTAC) with enhanced catalytic activity and in vivo properties.

EGF-R (661-681) T669 Peptide	p38 MAPK	Others
EGF-R (661-681) T669 Peptide is a MAPK substrate that can used to measure MAPK catalytic activity .

HY-125954B

Uridine diphosphate galuronic acid trisodium UDP-α-D-galuronic acid trisodium	Biochemical Assay Reagents	Metabolic Disease
Uridine diphosphate galuronic acid (UDP-α-D-galuronic acid) trisodium is a cofactor that is formed by the catalytic activity of UDP-glucose dehydrogenase .

HY-B2188

S-Methyl-L-cysteine L-S-Methylcysteine	Reactive Oxygen Species	Neurological Disease Metabolic Disease
S-Methyl-L-cysteine is a natural product that acts as a substrate in the catalytic antioxidant system mediated by methionine sulfoxide reductase A (MSRA), with antioxidative, neuroprotective, and anti-obesity activities.

HY-12056

BIX02189 5+ Cited Publications	MEK ERK	Cancer
BIX02189 is a potent and selective MEK5 inhibitor with an IC₅₀ of 1.5 nM. BIX02189 also inhibits ERK5 catalytic activity with an IC₅₀ of 59 nM.

HY-162266

C3TD879

Others Metabolic Disease

C3TD879 is a potent Type I kinase inhibitor. C3TD879 inhibits CITK catalytic activity with an IC₅₀ of 12 nM .

C3TD879	Others	Metabolic Disease
C3TD879 is a potent Type I kinase inhibitor. C3TD879 inhibits CITK catalytic activity with an IC₅₀ of 12 nM .

HY-12055

BIX02188 3 Publications Verification	MEK ERK	Cancer
BIX02188 is a potent MEK5-selective inhibitor with an IC₅₀ of 4.3 nM. BIX02188 inhibits ERK5 catalytic activity, with an IC₅₀ of 810 nM.

HY-W327122

BAP1-IN-1

Others Cancer

BAP1-IN-1 (Compound 8) is a BRCA1 associated protein 1 (BAP1) catalytic activity inhibitor with an IC₅₀ of 0.1-1 μM .

BAP1-IN-1	Others	Cancer
BAP1-IN-1 (Compound 8) is a BRCA1 associated protein 1 (BAP1) catalytic activity inhibitor with an IC₅₀ of 0.1-1 μM .

HY-N10402

Norbatzelladine L	Fungal Bacterial Parasite	Infection Cancer
Norbatzelladine L (Compound 2) is an inhibitor of the catalytic and functional activity of Pdr5p transporter. Norbatzelladine L inhibits Pdr5p ATPase activity with an IC₅₀ of 3.8 µM. Norbatzelladine L shows antifungal, antiparasitic, antiviral, antibacterial and antitumoral activities .

HY-N6800A

Netropsin dihydrochloride	DNA/RNA Synthesis Bacterial Influenza Virus Antibiotic Orthopoxvirus	Infection Inflammation/Immunology
Netropsin dihydrochloride is a small-molecule MGB (minor-groove binder), inhibits the catalytic activity of isolated topoisomerase and interferes with the stabilization of the cleavable complexes of topoisomerase II and I in nuclei . Netropsin dihydrochloride exhibits antiviral activity against the vaccinia virus .

HY-N10401

Batzelladine D	Fungal Bacterial Parasite	Infection Cancer
Batzelladine D (Compound 1) is an inhibitor of the catalytic and functional activity of Pdr5p transporter. Batzelladine D inhibits Pdr5p ATPase activity with an IC₅₀ of 7.1 µM. Batzelladine D shows antifungal, antiparasitic, antiviral, antibacterial and antitumoral activities .

HY-N12399

Aplithianines A	PKA	Inflammation/Immunology
Aplithianines A is a potent inhibitor against J-PKA_cα with an IC₅₀ of 1 μM , and inhibits wild-type PKA with an IC₅₀ of 84 nM. Aplithianines A inhibits J-PKAcα catalytic activity by competitively binding to the ATP pocket .

HY-130644

iRucaparib-AP6 1 Publications Verification	PROTACs PARP	Cancer
iRucaparib-AP6 is a highly efficient and specific PROTAC PARP1 degrader. iRucaparib-AP6, a non-trapping PARP1 degrader, blocks both the catalytic activity and scaffolding effects of PARP1 .

HY-132233

DDO-2093	Histone Methyltransferase	Cancer
DDO-2093 is a potent MLL1-WDR5 protein-protein interaction inhibitor (IC₅₀=8.6 nM; K_d=11.6 nM) with antitumor activity. DDO-2093 selectively inhibits the catalytic activity of MLL complex .

HY-132233A

DDO-2093 dihydrochloride	Histone Methyltransferase	Cancer
DDO-2093 dihydrochloride is a potent MLL1-WDR5 protein-protein interaction inhibitor (IC₅₀=8.6 nM; K_d=11.6 nM) with antitumor activity. DDO-2093 dihydrochloride selectively inhibits the catalytic activity of MLL complex .

HY-155247

Tyrosinase-IN-14	Tyrosinase	Others
Tyrosinase-IN-14 (compound 7m) is a tyrosinase inhibitor that reduces the catalytic activity of tyrosinase by changing its secondary structure. Tyrosinase-IN-14 has low cytotoxicity and anti-browning activity in fruits. Tyrosinase-IN-14 effectively inhibits banana browning during storage .

HY-N6714

Alternariol	Topoisomerase	Infection Cancer
Alternariol is a mycotoxin produced by Alternaria species. AOH inhibits the catalytic activity of topoisomerase I and topoisomerase II enzymes . Alternariol exhibits a variety of therapeutic and biological properties such as phytotoxicity, cytotoxicity, anti-HIV, anti-cancer, and anti-microbial properties .

HY-149410

MSN8C	Others	Cancer
MSN8C, an analog of mansonone E, is a novel catalytic inhibitor of human DNA topoisomerase II. MSN8C induces cancer cell apoptosis. MSN8C shows significant anti-tumor cell proliferation activity in vitro .

HY-150073

DS01080522	Others	Cancer
DS01080522 is a Protein Kinase cAMP-Activated Catalytic Subunit Alpha (PRKACA) inhibitor. DS01080522 inhibits PRKACA kinase activity and CREB phosphorylation with IC₅₀s of 0.8 nM and 66 nM, respectively. DS01080522 can be used for the research of cancer .

HY-A0210

Cerulenin 5 Publications Verification	Fatty Acid Synthase (FASN) Fungal Apoptosis Antibiotic	Infection Metabolic Disease
Cerulenin, a potent, natural inhibitor of fatty acid synthase (FASN), is an epoxide produced by the fungus Cephalosporium caeruleus. Cerulenin inhibits topoisomerase I catalytic activity and augments SN-38-induced apoptosis. Cerulenin has antifungal and antitumor activies .

HY-112800

cyt-PTPε Inhibitor-1	Phosphatase	Metabolic Disease
cyt-PTPε Inhibitor-1 is a potent cytosolic protein tyrosine phosphatase epsilon (cyt-PTPε) inhibitor, binds to the catalytic domain of cyt-PTPε, blocks c-Src activation (dephosphorylation of c-Src), and exhibits anti-osteoclastic activity .

HY-N2127

Pinostrobin 1 Publications Verification	Apoptosis Ser/Thr Protease HSV Interleukin Related	Infection Cardiovascular Disease Neurological Disease Inflammation/Immunology Cancer
Pinostrobin is a flavonoid with anti-cancer, antioxidant, antiviral and neuroprotective activities. Pinostrobin has oral activity. Pinostrobin is a potent PCSK9 inhibitor that inhibits the catalytic activity of PCSK9. Pinostrobin can be used in the research of viral infections, cancer, leukemia, cardiovascular and cerebrovascular diseases, cirrhosis, inflammation and neurological diseases .

HY-E70076

Subtilisin, bacillus licheniformis Bacillopeptidaseb	Biochemical Assay Reagents	Others
Subtilisin (Compound proteinase) (EC 3.4.21.62) is a proteolytic enzyme, isolated from Bacillus licheniformis. Subtilisin (Compound proteinase) has catalytic activity in anhydrous dimethyl formamide. Subtilisin (Compound proteinase) can be used as a catalyst for easy coupling between sugars and amino acids .

HY-122594

BNS-22	Topoisomerase	Cancer
BNS-22 is a DNA topoisomerase II (TOP2) catalytic inhibitor with the IC₅₀ values of 2.8 μM and 0.42 μM for human TOP2α and TOP2β, respectively. BNS-22 induces abnormal division and has anti-proliferative activity .

HY-P4202

Suc-Ala-Glu-Pro-Phe-pNA Suc-AEPF-pNA	Biochemical Assay Reagents	Others
Suc-Ala-Glu-Pro-Phe-pNA (Suc-AEPF-pNA) is a chromogenic substrate for the peptidylprolyl isomerase Pin1. Suc-Ala-Glu-Pro-Phe-pNA can be used to evaluate the inhibitory effect of the target compound on Pin1, and catalytic activity of Pin1, etc .

HY-D0020

2,2'-Bipyridine	Biochemical Assay Reagents	Infection Endocrinology
2,2'-Bipyridine is the unique molecular scaffold of the bioactive natural products. 2,2'-Bipyridine is extensively used as the core structure of many chelating ligands by acting as a bridge in the arrangement of the catalytic center. 2,2'-Bipyridine shows robust redox stability and hyperglycemic activity .

HY-108900

Leu-AMS	Aminoacyl-tRNA Synthetase Bacterial	Infection Cancer
Leu-AMS (compound 6), a leucine analogue, is a potent inhibitor of leucyl-tRNA synthetase (LRS) with an IC₅₀ of 22.34 nM, which inhibits the catalytic activity of LRS but did not affect the leucine-induced mTORC1 activation. Leu-AMS shows cytotoxicity in cancer cells and normal cells, and inhibits the growth of bacteria .

HY-P4202A

Suc-Ala-Glu-Pro-Phe-pNA TFA Suc-AEPF-pNA TFA	Biochemical Assay Reagents	Others
Suc-Ala-Glu-Pro-Phe-pNA (Suc-AEPF-pNA ) TFA is a chromogenic substrate for the peptidylprolyl isomerase Pin1. Suc-Ala-Glu-Pro-Phe-pNA TFA can be used to evaluate the inhibitory effect of the target compound on Pin1, and catalytic activity of Pin1, etc .

HY-111086

DG70 GSK1733953A	Bacterial	Infection
DG70 (GSK1733953A), a biphenyl amide, is a respiration inhibitor in Mycobacterium tuberculosis, inhibits MenG activity with an IC₅₀ value of 2.6 ± 0.6 μM. DG70 inhibits the catalytic methylation of Mycobacterium tuberculosis demethylmenaquinone methyltransferase enzymes. DG70 can be used for Tuberculosis (TB) research .

HY-149668

α-Glucosidase-IN-41	Glucosidase	Metabolic Disease
α-Glucosidase-IN-41 (compound 5o) is a potent α-glucosidase inhibitor. α-Glucosidase-IN-41 can arise the changed secondary structure of α-Glu to hinder enzyme catalytic activity. α-Glucosidase-IN-41 can be used for diabetes mellitus research .

HY-103195

NKY80 1 Publications Verification	Adenylate Cyclase	Metabolic Disease
NKY80 is a potent, selective and non-competitive adenylyl cyclase (AC) type V isoform inhibitor with IC₅₀s of 8.3 µM, 132 µM and 1.7 mM for type V, III and II, respectively. NKY80 is a non-nucleoside quinazolinone and regulates the AC catalytic activity in heart and lung tissues .

HY-124514

UC-857993	Ras ERK	Cancer
UC-857993 is a selective SOS1-Ras inhibitor (K_d=14.7 μM, His₆-SOS1_cat), suppressing catalytic activity. UC-857993 also inhibits ERK and Ras activation, suppresses the growth of mouse embryonic fibroblasts (MEFs) .

HY-13821

Epoxomicin 5+ Cited Publications BU-4061T	Proteasome Apoptosis	Inflammation/Immunology Cancer
Epoxomicin (BU-4061T) is an epoxyketone-containing natural product and a potent, selective and irreversible proteasome inhibitor. Epoxomicin covalently binds to the LMP7, X, MECL1, and Z catalytic subunits of the proteasome and potently inhibits primarily the chymotrypsin-like activity. Epoxomicin can cross the blood-brain barrier. Epoxomicin has strongly antitumor and anti-inflammatory activity .

HY-128463

N-tert-Butyl-α-phenylnitrone	COX Reactive Oxygen Species	Neurological Disease Metabolic Disease Inflammation/Immunology
N-tert-Butyl-α-phenylnitrone is a nitrone-based free radical scavenger that forms nitroxide spin adducts. N-tert-Butyl-α-phenylnitrone inhibits COX2 catalytic activity. N-tert-Butyl-α-phenylnitrone has potent ROS scavenging, anti-inflammatory, neuroprotective, anti-aging and anti-diabetic activities, and can penetrate the blood-brain barrier .

HY-148161

L82-G17	DNA/RNA Synthesis	Cancer
L82-G17 is an uncompetitive DNA ligase I (Lig I)-selective inhibitor. L82-G17 inhibits the third step of the ligation reaction, phosphodiester bond formation. L82-G17can be used as a probe of the catalytic activity .

HY-W728451

URB694	FAAH	Cardiovascular Disease Neurological Disease
URB694 is a carbamate FAAH inhibitor that irreversibly carbamoylate the nucleophile catalytic serine in FAAH active site. URB694 exhibits antidepressant-like activity and cardioprotective effects. URB694 can be used to prepare ¹¹C-Carbonyl-URB694 for in vivo positron emission tomography (PET) imaging studies of the brain FAAH .

HY-11107

PHA-665752 Maximum Cited Publications 11 Publications Verification	c-Met/HGFR Autophagy Apoptosis	Cancer
PHA-665752 is a selective, ATP-competitive, and active-site inhibitor of the catalytic activity of c-Met kinase (K_i=4 nM; IC₅₀=9 nM). PHA-665752 exhibits >50-fold selectivity for c-Met compared with a panel of diverse tyrosine and serine-threonine kinases. PHA-665752 induces apoptosis and cell cycle arrest, and exhibits cytoreductive antitumor activity .

HY-147313

TH10785	Others	Metabolic Disease Cancer
TH10785 is a DNA glycosylase 1 (OGG1) activator, TH10785 can interact with the phenylalanine-319 and glycine-42 amino acids of OGG1 and increase the enzyme activity, generates β, δ-lyase enzymatic function. TH10785 can control the catalytic activity mediated by a nitrogen base within its molecular structure. TH10785 can be used for the research of various diseases and aging connected with DNA oxidative lesions .

HY-16124

Canfosfamide TLK-286; TER286	DNA-PK Apoptosis	Cancer
Canfosfamide (TLK-286, TER286) is a glutathione analogue prodrug that is activated by glutathione S-transferase P1-1 and induces apoptosis. Canfosfamide also inhibits the catalytic kinase activity of DNA-dependent protein kinase (DNA-PK). Canfosfamide produces an anticancer alkylating agent and a glutathione derivative after activation. Canfosfamide can be used to research malignancies .

HY-124308

PS315	PKC	Cancer
PS315, a derivative of PS48 (HY-15967), is an allosteric PKC inhibitor by binding to the PIF-pocket of aPKC and inducing a displacement of the active site residue Lys111. PS315 inhibits the full-length and catalytic domain constructs of PKC_ζ (IC₅₀=10 μM) and PKC_η (IC₅₀=30 μM). PS315 has anti-cancer activity .

HY-134019

Arachidonoyl p-nitroaniline	Others	Others
Arachidonoyl p-nitroaniline is a substrate for the hydrolysis of p-nitroaniline by FAAH in Dictyostelium discoideum with long-chain unsaturated fatty acids. Arachidonoyl p-nitroaniline can be used in enzyme kinetic studies. Examples include determining the hydrolysis rate of Arachidonoyl p-nitroaniline and analyzing the fatty acid amide hydrolase activity of recombinant His-FAAH purified from Dictyostelium to characterize the binding and catalytic specificity of mammalian FAAH enzymes .

HY-125954A

Uridine diphosphate glucuronic acid ammonium UDP-α-D-glucuronic acid ammonium	Endogenous Metabolite	Metabolic Disease
Uridine diphosphate glucuronic acid (UDP-GlcA) ammonium is a cofactor that is formed by the catalytic activity of UDP-glucose dehydrogenase. Uridine diphosphate glucuronic acid (ammonium) is a central precursor in sugar nucleotide biosynthesis and common substrate for C4-epimerases and decarboxylases releasing UDP-galacturonic acid (UDP-GalA) and UDP-pentose products, respectively. Uridine diphosphate glucuronic acid (ammonium), as a glucuronic acid donor, can be used for for the research of the conjugation of bilirubin in the endoplasmic recticulum .

Cat. No.	Product Name	Type

HY-15932

TOOS

TOOS sodium salt

Biochemical Assay Reagents

TOOS (TOOS sodium salt) is a highly water-soluble aniline derivative widely used in diagnostics and biological experiments. TOOS can be combined with 3-methyl-2-benzothiazolinone hydrazone hydrochloride (MBTH) to form a chromogenic system to measure oxidase activity. In the MBTH-TOOS chromogenic system, MBTH is catalytically oxidized to produce (-NH) free radicals, which react with TOOS to form colorless compounds. Furthermore, the colorless compound undergoes a disproportionation reaction to produce a blue-violet quinoid compound .

HY-W075707

FeTCPP

Iron(III) meso-Tetra(4-carboxyphenyl)porphine chloride

Biochemical Assay Reagents

FeTCPP (Iron(III) meso-Tetra(4-carboxyphenyl)porphine chloride) is a metallic porphyrin compound formed by the coordination of a central iron ion (Fe ³⁺) with four 4-carboxyphenylporphyrins (TCPP). FeTCPP can be used as a catalyst for catalytic, electrochemical, photochemical and biomedical research. FeTCPP has high photocatalytic performance for p-nitrophenol under visible light. FeTCPP also has peroxisase-like activity, which is used in bionic catalysis research .

HY-W020985

Bis[1,2-bis(diphenylphosphino)ethane]palladium(0)

Pd(DIPHOS)2

Biochemical Assay Reagents

Bis[1,2-bis(diphenylphosphino)ethane]palladium(0), often abbreviated as Pd(PPh3)2 or Pd(dppf), is an organometallic compound. This compound is widely used as a catalyst for organic chemical reactions, especially cross-coupling reactions such as Suzuki-Miyaura reaction and Heck reaction, and its high catalytic activity, selectivity and stability make it a versatile tool for the synthesis of complex organic compounds , in addition, the potential application of Pd(PPh3)2 in the production of electronic materials and in medical and biochemical research has also been investigated.

HY-125954A

Uridine diphosphate glucuronic acid ammonium

UDP-α-D-glucuronic acid ammonium

Biochemical Assay Reagents

Uridine diphosphate glucuronic acid (UDP-GlcA) ammonium is a cofactor that is formed by the catalytic activity of UDP-glucose dehydrogenase. Uridine diphosphate glucuronic acid (ammonium) is a central precursor in sugar nucleotide biosynthesis and common substrate for C4-epimerases and decarboxylases releasing UDP-galacturonic acid (UDP-GalA) and UDP-pentose products, respectively. Uridine diphosphate glucuronic acid (ammonium), as a glucuronic acid donor, can be used for for the research of the conjugation of bilirubin in the endoplasmic recticulum .

Cat. No.	Product Name	Target	Research Area

HY-P2208

Z-IETD-AFC

Fluorescent Dye Cancer

Z-IETD-AFC, a specific fluorescence substrate, can be used to determine the caspase-8 catalytic activity .

HY-P3414A

Proteasome-activating peptide 1 TFA 1 Publications Verification	Proteasome	Neurological Disease
Proteasome-activating peptide 1 TFA is a peptide and a potent proteasome activator. Proteasome-activating peptide 1 TFA increases the chymotrypsin-like proteasomal catalytic activity and, consequently, proteolytic rates both in vitro and in culture. Proteasome-activating peptide 1 TFA prevents protein aggregation in a cellular model of amyotrophic lateral sclerosis .

HY-P3811A

Autocamtide-3 acetate	CaMK	Neurological Disease
Autocamtide-3 acetate, a 13-amino-acid peptide containing Thr287, is a selective CaMKII (Ca ²⁺/calmodulin-dependent kinase II) (CaMK) substrate .

HY-P3414

Proteasome-activating peptide 1	Peptides	Neurological Disease
Proteasome-activating peptide 1 is a peptide, which increases the chymotrypsin-like proteasomal catalytic activity and, consequently, proteolytic rates both in vitro and in culture. Proteasome-activating peptide 1 prevents protein aggregation in a cellular model of amyotrophic lateral sclerosis .

HY-P3811

Autocamtide-3

CaMK Neurological Disease

Autocamtide-3, a 13-amino-acid peptide containing Thr287, is a selective CaMKII (Ca ²⁺/calmodulin-dependent kinase II) (CaMK) substrate .
HY-P3918

EGF-R (661-681) T669 Peptide

p38 MAPK Others

EGF-R (661-681) T669 Peptide is a MAPK substrate that can used to measure MAPK catalytic activity .

HY-P4147

Ac-IHIHIQI-NH2	Peptides	Others
Ac-IHIHIQI-NH2 is a fibril-forming heptapeptide with high catalytic activity to laccase mimics. Ac-IHIHIQI-NH2 exhibits selectivity for hydrophobic p-nitrophenyl (ONp) ester substrates in the process of self-assembly .

HY-P4202

Suc-Ala-Glu-Pro-Phe-pNA Suc-AEPF-pNA	Biochemical Assay Reagents	Others
Suc-Ala-Glu-Pro-Phe-pNA (Suc-AEPF-pNA) is a chromogenic substrate for the peptidylprolyl isomerase Pin1. Suc-Ala-Glu-Pro-Phe-pNA can be used to evaluate the inhibitory effect of the target compound on Pin1, and catalytic activity of Pin1, etc .

HY-P4202A

Suc-Ala-Glu-Pro-Phe-pNA TFA Suc-AEPF-pNA TFA	Biochemical Assay Reagents	Others
Suc-Ala-Glu-Pro-Phe-pNA (Suc-AEPF-pNA ) TFA is a chromogenic substrate for the peptidylprolyl isomerase Pin1. Suc-Ala-Glu-Pro-Phe-pNA TFA can be used to evaluate the inhibitory effect of the target compound on Pin1, and catalytic activity of Pin1, etc .

HY-P4727

(β-Asp5)-Delta-Sleep Inducing Peptide DSIP-isoD	Peptides	Others
(β-Asp5)-Delta-Sleep Inducing Peptide (DSIP-isoD) is a synthetic polypeptide that can be partially hydrolyzed by NaOH or SDS. (β-Asp5)-Delta-Sleep Inducing Peptide can be used to study the catalytic activity of mitochondrial protein L-isoaspartyl (D-aspartyl) methyltransferase (PIMT) .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-B2188

S-Methyl-L-cysteine L-S-Methylcysteine	Structural Classification other families Ketones, Aldehydes, Acids Source classification Plants	Reactive Oxygen Species
S-Methyl-L-cysteine is a natural product that acts as a substrate in the catalytic antioxidant system mediated by methionine sulfoxide reductase A (MSRA), with antioxidative, neuroprotective, and anti-obesity activities.

HY-N6800A

Netropsin dihydrochloride	Classification of Application Fields Inflammation/Immunology Disease Research Fields	DNA/RNA Synthesis Bacterial Influenza Virus Antibiotic Orthopoxvirus
Netropsin dihydrochloride is a small-molecule MGB (minor-groove binder), inhibits the catalytic activity of isolated topoisomerase and interferes with the stabilization of the cleavable complexes of topoisomerase II and I in nuclei . Netropsin dihydrochloride exhibits antiviral activity against the vaccinia virus .

HY-N2912

Axillaridine A	Structural Classification Buxaceae Terpenoids Source classification Diterpenoids Sarcococca hookeriana Baill. Sarcococca hookeriana var. digyna Franch. Plants	Cholinesterase (ChE)
Axillaridine A can be isolated from Sarcococca hookeriana var. digyna. Axillaridine A inhibits the catalytic activity of AChE .

HY-N10402

Norbatzelladine L	Alkaloids Microorganisms Source classification	Fungal Bacterial Parasite
Norbatzelladine L (Compound 2) is an inhibitor of the catalytic and functional activity of Pdr5p transporter. Norbatzelladine L inhibits Pdr5p ATPase activity with an IC₅₀ of 3.8 µM. Norbatzelladine L shows antifungal, antiparasitic, antiviral, antibacterial and antitumoral activities .

HY-N10401

Batzelladine D	Infection Alkaloids Structural Classification Classification of Application Fields Animals Other Alkaloids Marine natural products Sponge Disease Research Fields Cancer	Fungal Bacterial Parasite
Batzelladine D (Compound 1) is an inhibitor of the catalytic and functional activity of Pdr5p transporter. Batzelladine D inhibits Pdr5p ATPase activity with an IC₅₀ of 7.1 µM. Batzelladine D shows antifungal, antiparasitic, antiviral, antibacterial and antitumoral activities .

HY-N12399

Aplithianines A	Structural Classification Alkaloids Microorganisms Other Alkaloids Source classification	PKA
Aplithianines A is a potent inhibitor against J-PKA_cα with an IC₅₀ of 1 μM , and inhibits wild-type PKA with an IC₅₀ of 84 nM. Aplithianines A inhibits J-PKAcα catalytic activity by competitively binding to the ATP pocket .

HY-N6714

Alternariol	Infection Microorganisms Classification of Application Fields Source classification Phenols Polyphenols Disease Research Fields	Topoisomerase
Alternariol is a mycotoxin produced by Alternaria species. AOH inhibits the catalytic activity of topoisomerase I and topoisomerase II enzymes . Alternariol exhibits a variety of therapeutic and biological properties such as phytotoxicity, cytotoxicity, anti-HIV, anti-cancer, and anti-microbial properties .

HY-A0210

Cerulenin 5 Publications Verification	Structural Classification Microorganisms Antifungal Classification of Application Fields Antibiotics Source classification Metabolic Disease Mammalian Cell Culture Disease Research Anticancer Disease Research Fields Other Antibiotics	Fatty Acid Synthase (FASN) Fungal Apoptosis Antibiotic
Cerulenin, a potent, natural inhibitor of fatty acid synthase (FASN), is an epoxide produced by the fungus Cephalosporium caeruleus. Cerulenin inhibits topoisomerase I catalytic activity and augments SN-38-induced apoptosis. Cerulenin has antifungal and antitumor activies .

HY-N2127

Pinostrobin 1 Publications Verification	Structural Classification Monophenols Flavonoids other families Classification of Application Fields Flavonones Source classification Phenols Plants Inflammation/Immunology Disease Research Fields	Apoptosis Ser/Thr Protease HSV Interleukin Related
Pinostrobin is a flavonoid with anti-cancer, antioxidant, antiviral and neuroprotective activities. Pinostrobin has oral activity. Pinostrobin is a potent PCSK9 inhibitor that inhibits the catalytic activity of PCSK9. Pinostrobin can be used in the research of viral infections, cancer, leukemia, cardiovascular and cerebrovascular diseases, cirrhosis, inflammation and neurological diseases .

HY-13821

Epoxomicin Maximum Cited Publications 7 Publications Verification BU-4061T	Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Inflammation/Immunology Disease Research Fields	Proteasome Apoptosis
Epoxomicin (BU-4061T) is an epoxyketone-containing natural product and a potent, selective and irreversible proteasome inhibitor. Epoxomicin covalently binds to the LMP7, X, MECL1, and Z catalytic subunits of the proteasome and potently inhibits primarily the chymotrypsin-like activity. Epoxomicin can cross the blood-brain barrier. Epoxomicin has strongly antitumor and anti-inflammatory activity .

HY-125954A

Uridine diphosphate glucuronic acid ammonium UDP-α-D-glucuronic acid ammonium	Structural Classification Natural Products Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
Uridine diphosphate glucuronic acid (UDP-GlcA) ammonium is a cofactor that is formed by the catalytic activity of UDP-glucose dehydrogenase. Uridine diphosphate glucuronic acid (ammonium) is a central precursor in sugar nucleotide biosynthesis and common substrate for C4-epimerases and decarboxylases releasing UDP-galacturonic acid (UDP-GalA) and UDP-pentose products, respectively. Uridine diphosphate glucuronic acid (ammonium), as a glucuronic acid donor, can be used for for the research of the conjugation of bilirubin in the endoplasmic recticulum .

Cat. No.	Product Name	Chemical Structure

HY-128463S

N-tert-Butyl-α-phenylnitrone-d14

N-tert-Butyl-α-phenylnitrone-d₁₄ is the deuterium labeled N-tert-Butyl-α-phenylnitrone[1]. N-tert-Butyl-α-phenylnitrone is a nitrone-based free radical scavenger that forms nitroxide spin adducts. N-tert-Butyl-α-phenylnitrone inhibits COX2 catalytic activity. N-tert-Butyl-α-phenylnitrone has potent ROS scavenging, anti-inflammatory, neuroprotective, anti-aging and anti-diabetic activities, and can penetrate the blood-brain barrier[2][3][4][5].

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